"Nobody Knows You When You're Down and Out" is the 4th track from the album "Layla and Other Assorted love Songs" by Derek and the Dominos. When he was an art student in the early 1960s, Eric Clapton was attracted to London's folk-music scene and the fingerpicking acoustic guitar-style of Big Bill Broonzy. Along with "Key to the Highway", "Nobody Knows You When You're Down and Out" was one of the first songs that Clapton learned to play in this style. In 1970, he recorded a group version with his band, Derek and the Dominos, for their debut album Layla and Other Assorted Love Songs. The recording took place at the Criteria Studios in Miami, Florida, with Jim Gordon (drums), Carl Radle (bass), Bobby Whitlock (organ), and Duane Allman (slide guitar). As Whitlock recalled, Sam Samudio, who was also recording at Criteria, suggested that they record the song. This was Duane Allman's first song with us. I believe that it was a song that he and Eric both had in common. This song was recorded live, vocals and all, with no overdubs. It was the first take, but of course it was all worked out before we went into it. Allman had recorded "Nobody Knows You When You're Down and Out" earlier with his brother Gregg and used similar guitar lines for the Derek and the Dominos recording. Whitlock also noted that Clapton played through a Fender Champ guitar amplifier (a five-watt practice amp), while Allman used a Fender Twin.